Scientific Programme

September 1 - 4, 2024 | Cambridge, UK

Sunday, 1st September

12:30 – 14:00
Registration

Check-In + set-up Posters

14:00 – 14:15
Welcome and Introduction

Sandip Patel

14:15 – 15:15

Annette Draeger Opening Lecture

Speaker Annette Dolphin (UCL): Lessons in drugs and trafficking from voltage-gated calcium channels

Chair Sandip Patel (UCL)

15:15 – 16:45

Session 1: Plasma membrane – ER junctions: hubs for local and global calcium signaling

Chair Indu Ambukdar (NIH/NIDCR)

Genevieve Dupont (Université Libre de Bruxelles): Computational insights into the molecular mechanism of T cells microdomains formation

Bjorn Diercks (University Medical Center Hamburg-Eppendorf): Initial Ca2+ microdomains in T cells

Isabella Derler (Johannes Kepler University Linz): Photocrosslinking: a novel tool to study Orai1 channel dynamics

Session discussion

16:45
Coffee / Tea Break
17:15 – 18:45

Session 2: Functional and dysfunctional states of calcium binding proteins

Chair Daniele Dell’Orco (University of Verona)

Alessandra Astegno (University of Verona): The Large Repertoire of Calmodulin-related Proteins in Plants and Parasites

James Ames (University of California at Davies): Structural Basis of L-type Channel Regulation by Calmodulin and CaBP1

Short talk selected from abstract submissions

Short talk selected from abstract submissions

Session discussion

18:45 – 21:30

Welcome Reception & Dinner

Monday, 2nd September 

8:30 – 9:00
Refreshments 
9:00 – 10:30

Session 3: Organelle-cross talk

Chair Mohammed Trebak (University of Pittsburgh)

Rajender Motiani (Regional Centre for Biotechnology): Calcium driven inter-organelle crosstalk: A master regulator of vertebrate pigmentation

Jen Liou (UT Southwestern Medical Center): Regulation of receptor-induced PIP2-Calcium Signaling at ER-PM junctions by Nir proteins

Anna Raffaello (University of Padova): New modulators of mitochondrial calcium uptake

Session discussion

10:30 
Coffee / Tea Break
11:00 – 12:30

Session 4: Calcium signalling in disease

Chair Khaled Machaca (Weill Cornell Medicine – Qatar)

Greg Monteith (University of Queensland): Pathways to targeting calcium channels for cancer therapy

Mo Trebak (University of Pittsburgh): Calcium signaling through Orai channels in health and disease

Short talk selected from abstract submissions

Short talk selected from abstract submissions

Session discussion

12:30 – 13:00

Flash Talks 1

Chair Ana Rossi (University of Cambridge)

13:00 – 14:30

Lunch with Poster Session 1

 

14:30 – 16:00

Session 5: New calcium imaging technologies

Chair Robert Campbell (University of Tokyo), co-chair Shosei Imai

Hod Dana (Case Western Reserve University): Development and application of a high-sensitivity version of the calcium-sensitive activity integrator CaMPARI

Claire Deo (EMBL): Chemigenetic molecular tools for photoacoustic imaging of neural activity

Short talk selected from abstract submissions

Short talk selected from abstract submissions

Session discussion

16:00
Coffee / Tea Break
16:30 – 18:00

Session 6: Advances in NAADP signaling

Chair Eugen Brailiou (Temple University)

Jonathan Marchant (Medical College of Wisconsin): Characterizing the role of Jupiter microtubule-associated homolog 2 (JPT2) in NAADP-evoked Ca2+ release from acidic Ca2+ stores.

Jiusheng Yan (University of Texas): Crosstalk between NAADP and PI(3,5)P2 signaling mediated by Lsm12 and two-pore channels

Yongjuan Zhao (CUHK-Shenzhen): Unraveling the Biosynthesis and Degradation of Cyclic ADP-Ribose: Implications for Neuronal Function and Neurodegeneration

Session discussion

18:00 – 18:30

jECS Session

Chair Gaia Gherardi (University of Padova)

This session will consist of two speakers selected at the jECS meeting. 

Speaker 1 – TBA

Speaker 2 – TBA

Session discussion

 

 

19:30

Dinner

Bar & Posters

The college bar is open during and following dinner.

Tuesday, 3rd September

8:30 – 9:00 
Refreshments 
9:00 – 10:30

Session 7: New discoveries in the structure and function of calcium transport ATPases

Chair Agnes Enyedi (Semmelweis University, Hungary), co-chair Sarolta Tóth

Jason Bruce (The University of Manchester): Fuelling PMCA in pancreatic diseases

Elizabeth Cartwright (University of Manchester): The pathophysiological role of PMCAs in heart failure and hypertension

Dirk Montag (Leibniz Institute for Neurobiology): The PMCA – neuroplastin liason is essential for hearing and associative learning and memory

Session discussion

10:30
Coffee / Tea Break
11:00 – 12:30

Session 8: The role of allostery in calcium signalling

Chair David Weber (University of Maryland)

Gary Shaw (University of Western Ontario): Coupling of Binding Sites in S100 Proteins

Speaker TBA 

Short talk selected from abstract submissions

Short talk selected from abstract submissions

Session discussion

12:30 – 16:30

Free Time

16:30 – 17:30

General Assembley

17:30 – 18:30 

Claude Klee Lecture

Speaker: Martha Cyert (Stanford, USA): Discovering new mechanisms for calcineurin signaling

Chair: Jim Putney

19:30

BBQ 

Bar & Posters

The BBQ takes place in the college gardens. The college bar is open during and following dinner.

Wednesday, 4th September

8:30 – 9:00
Refreshments 
9:00 – 10:30

Session 9: Artificial intelligence

Chair Jonathan Marchant (Medical College of Wisconsin), co-chair Sushil Kumar

Andreas Bender (University of Cambridge): Artificial Intelligence in Chemical and Biology and Drug Discovery – Methods, Applications, and Pitfalls

 Lukas Friedrich (Merck Healthcare KGaA): Industrial Applications of Machine Learning in Early Drug Discovery

Short talk selected from abstract submissions

Short talk selected from abstract submissions

Session discussion

 

10:30
Coffee / Tea Break
11:00 – 12:30

Session 10: Annexins and the S100 proteins

Chair Ursula Rescher (University of Münster), co-chair Inga Pauels

Jesper Nylandsted (Danish Cancer Institute (DCI), Copenhagen): Ca2+-Guided Plasma Membrane Repair Mediated by Annexin Proteins

Axel Brakhage (Leibniz Institute for Natural Product Research and Infection Biology): Pathogenic fungus hijacks human S100A10 (p11) to redirect fungal-containing phagosomes to non-degradative pathway

Short talk selected from abstract submissions

Short talk selected from abstract submissions

Session discussion

12:30 – 13:00 

Flash Talks 2

Chair Martin Bootman (The Open University)

13:00 – 14:30

Lunch with Poster Session 2

 

14:30 – 16:00

Session 11: Calcium signaling at membrane contact sites

Chair Nicolas Demaurex (Univeristy of Geneva), co-chair Raphaël Néré

Jennifer Rieusset (Claude Bernard University Lyon): ER-mitochondria interactions and calcium coupling in metabolic health and diseases.

Raz Palty (Israel Institute of Technology): STIM1 recruitment and signaling at ER-PM contact sites

Alex van Vliet (MRC Laboratory of Molecular Biology in Cambridge): Autophagy Initiation through (rapid) membrane contact sites

Session discussion

16:00
Coffee / Tea Break
16:30 – 17:30

Late Breaking Session

Chair Geert Bultynck (KU Leuven) , co-chair Femke Speelman-Rooms

Marja Jäättelä (Danish Cancer Institute, Copenhagen): Control of Lysosomal Ion Homeostasis

Wolfgang Graier (Medical University of Graz): Annexin-A5 is fundamental for mitochondrial Ca2+ homeostasis and determines the susceptibility to apoptosis

Session discussion

17:30 – 18:30

Sir Michael Berridge Lecture

Speaker Gaiti Hasan (NCBS, India): Integration of neuromodulatory inputs by intracellular Ca2+ signaling for systemic growth and behaviour

Chair Andreas Guse 

18:30
Concluding Remarks and Awards

by the local organising committee

19:30

Gala Dinner

The gala dinner takes place in the new dining hall. The college bar is open following dinner.

Sponsors

Thank you to our sponsors for making this event a success.

ECS Membership
Practical Information (registration fees, posters, oral communications, ...)